4-(OR 5-)HYDROXYMETHYL-2-THIOLIMIDAZOLE
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چکیده
منابع مشابه
Synthesis of 5-acetoxymethyl- and 5-hydroxymethyl-2-vinyl-furan.
5-Acetoxymethyl- and 5-hydroxymethyl-2-vinylfuran were synthesized by two routes. The first route starts from 2-methylfuran and the second from furfuryl acetate. The latter route, involving successive Vilsmeier-Haack and Wittig reactions, is suitable for producing 5-acetoxymethyl-2-vinylfuran and 5-hydroxymethyl-2 vinylfuran in 68% and 60%yields, respectively.
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In the title compound, C(12)H(24)O(4), the dioxane ring adopts a chair conformation; the n-hexyl chain, which occupies an equatorial position, has an extended zigzag conformation. In the crystal, mol-ecules are connected by O-H⋯O hydrogen-bonds into a zigzag chain running along the b axis, giving rise to a herringbone pattern.
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A novel and facile synthesis of 5-hydroxy-4-hydroxymethyl-2-cyclohexenylguanine 1 is described. The key steps involve a Diels-Alder reaction of ethyl (2E)-3-acetyloxy-2-propenoate 2 as dienophile with Danishefsky's diene 3 to build up the six-membered ring skeleton, a Fraser-Reid reductive rearrangement of the adduct using LiAlH(4), and base-moiety introduction using a Mitsunobu reaction. Optic...
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5-Hydroxymethyluracil (HmUra) is formed from thymine in DNA through the action of ionizing radiation or reactive oxygen species generated by activated leukocytes. HmUra is removed from DNA by a specific DNA glycosylase, suggesting that it is also formed from endogenously generated reactive oxygen species and that its formation in DNA is potentially deleterious. To determine whether HmUra residu...
متن کامل(E)-4-Methyl-2-{[tris(hydroxymethyl)methyl]iminiomethyl}phenolate
In the zwitterionic title compound, C(12)H(17)NO(4), an intra-molecular N-H⋯O hydrogen bond generates a six-membered ring, producing an S(6) ring. In the crystal structure, mol-ecules are linked by inter-molecular C-H⋯O and O-H⋯O inter-actions.
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1933
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(20)70815-x